Bilayer Stabilized Iron-oxide Nanoparticles: a Drug Carrier System for Anticancer Agents

Dr Marco Morales Department of Physics & Astronomy, and Nebraska Center for Materials and Nanoscience, University of Nebraska - Lincoln.

Magnetic nanoparticles offer exciting new opportunities towards developing effective drug-delivery systems. An external localized magnetic-field gradient may be applied to attract drug-loaded magnetic nanoparticles from blood circulation. Drug targeting to tumors, as well as other pathological conditions, is desirable since anticancer agents demonstrate non-specific toxicities that significantly limit their therapeutic potentials A novel water-dispersible oleic acid-Pluronic-coated iron-oxide magnetic nanoparticle formulation is developed that can be loaded with water-insoluble anticancer agents. Neither the formulation components nor the drug loading affected the magnetic properties of the core iron-oxide nanoparticles. Sustained release of the incorporated drug is observed over two weeks under in vitro conditions. The nanoparticles demonstrated dose-dependent antiproliferative effect in breast and prostate cancer cell lines.

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